Sermorelin: Benefits, Dosage & FDA Status
Sermorelin Acetate (GHRH 1-29)
The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.
FDA Status
FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies
Typical Dose
200–500 mcg before bed (subcutaneous)
Evidence Grade
B+Multiple clinical studies + widespread clinical use
Half-Life
~10–20 minutes
Routes of Administration
subcutaneous
First Synthesized
1980
Clinics Indexed
220 providers have offered Sermorelin in our tracked directory.
Mechanism of Action
Truncated GHRH(1–29) that activates pituitary GHRH receptors to drive endogenous pulsatile GH secretion.
Key Reported Benefits
- ✓Natural GH release
- ✓Improved sleep
- ✓Lean body mass
- ✓Recovery
Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade B+ indicates multiple clinical studies + widespread clinical use.
Reported Side Effects
- •Injection-site reactions
- •Flushing
- •Headache (rare)
Contraindications
- ⚠Active malignancy
- ⚠Severe obesity (blunted response)
- ⚠Pregnancy
Commonly Stacked With
Regulatory & Safety Context
FDA status: FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies
This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.
See state-by-state legality: US peptide legality by state →
References
Selected primary literature on Sermorelin. Full PubMed records linked. Additional citations are available on request.
Last reviewed: 2026-04-30
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