GHK-Cu vs Sermorelin
Both GHK-Cu and Sermorelin are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.
GHK-Cu
Evidence B+Copper Peptide GHK-Cu
A naturally occurring copper-binding tripeptide that modulates 4,000+ human genes. The most studied peptide for skin rejuvenation with both preclinical and clinical topical evidence.
View full GHK-Cu profile →Sermorelin
Evidence B+Sermorelin Acetate (GHRH 1-29)
The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.
View full Sermorelin profile →Side-by-Side
| Attribute | GHK-Cu | Sermorelin |
|---|---|---|
| Evidence Grade | B+ | B+ |
| FDA Status | Not FDA-approved — available as cosmetic ingredient and research compound | FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies |
| Typical Dose | 1–2 mg daily SC or topical (5 days on / 2 off) | 200–500 mcg before bed (subcutaneous) |
| Clinics Indexed | 145 | 220 |
| Categories | anti-aging, skin, hair | growth-hormone, anti-aging |
Key reported benefits — GHK-Cu
- ✓Collagen synthesis
- ✓Wrinkle reduction
- ✓Hair growth
- ✓Wound healing
Key reported benefits — Sermorelin
- ✓Natural GH release
- ✓Improved sleep
- ✓Lean body mass
- ✓Recovery
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.