What is the difference between CJC-1295 (no DAC) and Sermorelin?

CJC-1295 (no DAC) (Modified Growth Hormone Releasing Factor 1-29) is graded B and is Not FDA-approved — Category 1 (compounding allowed). Sermorelin (Sermorelin Acetate (GHRH 1-29)) is graded B+ and is FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies. They are commonly compared because they share the categories: growth-hormone, anti-aging.

Which has stronger clinical evidence — CJC-1295 (no DAC) or Sermorelin?

On our internal evidence scale, CJC-1295 (no DAC) is B and Sermorelin is B+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of CJC-1295 (no DAC) vs Sermorelin?

CJC-1295 (no DAC): 100–300 mcg before bed (subcutaneous). Sermorelin: 200–500 mcg before bed (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

CJC-1295 (no DAC) vs Sermorelin

Both CJC-1295 (no DAC) and Sermorelin are used for growth-hormone and anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.

CJC-1295 (no DAC)

Evidence B

Modified Growth Hormone Releasing Factor 1-29

A growth hormone releasing hormone (GHRH) analog most commonly stacked with Ipamorelin to stimulate natural GH pulsatile release without disrupting the hypothalamic axis.

View full CJC-1295 (no DAC) profile →

Sermorelin

Evidence B+

Sermorelin Acetate (GHRH 1-29)

The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.

View full Sermorelin profile →

Side-by-Side

Attribute	CJC-1295 (no DAC)	Sermorelin
Evidence Grade	B	B+
FDA Status	Not FDA-approved — Category 1 (compounding allowed)	FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies
Typical Dose	100–300 mcg before bed (subcutaneous)	200–500 mcg before bed (subcutaneous)
Clinics Indexed	156	220
Categories	growth-hormone, anti-aging, recovery	growth-hormone, anti-aging

Key reported benefits — CJC-1295 (no DAC)

✓Growth hormone release
✓Fat loss
✓Improved sleep
✓Muscle recovery

Key reported benefits — Sermorelin

✓Natural GH release
✓Improved sleep
✓Lean body mass
✓Recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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