What is the difference between Ipamorelin and Sermorelin?

Ipamorelin (Ipamorelin Acetate) is graded B and is Not FDA-approved — Category 1 (compounding allowed). Sermorelin (Sermorelin Acetate (GHRH 1-29)) is graded B+ and is FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies. They are commonly compared because they share the categories: growth-hormone, anti-aging.

Which has stronger clinical evidence — Ipamorelin or Sermorelin?

On our internal evidence scale, Ipamorelin is B and Sermorelin is B+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Ipamorelin vs Sermorelin?

Ipamorelin: 100–300 mcg before bed (subcutaneous). Sermorelin: 200–500 mcg before bed (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Ipamorelin vs Sermorelin

Both Ipamorelin and Sermorelin are used for growth-hormone and anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.

Ipamorelin

Evidence B

Ipamorelin Acetate

A selective growth hormone secretagogue that triggers GH release from the pituitary without significantly raising cortisol or prolactin. The safest GH peptide with the fewest side effects.

View full Ipamorelin profile →

Sermorelin

Evidence B+

Sermorelin Acetate (GHRH 1-29)

The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.

View full Sermorelin profile →

Side-by-Side

Attribute	Ipamorelin	Sermorelin
Evidence Grade	B	B+
FDA Status	Not FDA-approved — Category 1 (compounding allowed)	FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies
Typical Dose	100–300 mcg before bed (subcutaneous)	200–500 mcg before bed (subcutaneous)
Clinics Indexed	195	220
Categories	growth-hormone, anti-aging	growth-hormone, anti-aging

Key reported benefits — Ipamorelin

✓Clean GH release
✓Improved sleep quality
✓Fat reduction
✓Joint health

Key reported benefits — Sermorelin

✓Natural GH release
✓Improved sleep
✓Lean body mass
✓Recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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