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Evidence: BCognitive EnhancementAnxiety & Stress

Selank: Benefits, Dosage & FDA Status

Selank (TP-7)

A synthetic analog of tuftsin with anxiolytic and nootropic properties. Modulates GABA and serotonin systems to reduce anxiety without sedation.

FDA Status

Not FDA-approved in US — approved in Russia as anxiolytic

Typical Dose

200–400 mcg intranasal, evening

Evidence Grade

BLimited clinical + robust preclinical evidence

Half-Life

~30 minutes (effects last hours)

Routes of Administration

intranasal

First Synthesized

1995

Clinics Indexed

72 providers have offered Selank in our tracked directory.

Mechanism of Action

Tuftsin analog that enhances GABA-A signalling and modulates serotonergic and noradrenergic tone without benzodiazepine-like dependence.

Key Reported Benefits

Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade B indicates limited clinical + robust preclinical evidence.

Reported Side Effects

  • •Nasal irritation
  • •Drowsiness (rare)

Contraindications

  • ⚠Pregnancy
  • ⚠Severe psychiatric illness without supervision

Commonly Stacked With

Semax

A synthetic ACTH fragment that increases BDNF levels and enhances focus, memory, and mental clarity. Delivered intranasally for rapid cognitive effects.

Selank vs Other Peptides

Selank vs Semax→Selank vs Cerebrolysin→Selank vs Dihexa→Selank vs Pinealon→

Regulatory & Safety Context

FDA status: Not FDA-approved in US — approved in Russia as anxiolytic

This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.

See state-by-state legality: US peptide legality by state →

References

Selected primary literature on Selank. Full PubMed records linked. Additional citations are available on request.

  1. PubMed PMID 18365770
  2. PubMed PMID 26016890

Last reviewed: 2026-04-30

Related Peptides

Semax

B

A synthetic ACTH fragment that increases BDNF levels and enhances focus, memory, and mental clarity. Delivered intranasally for rapid cognitive effects.

Cerebrolysin

B

A standardized mixture of low-molecular-weight peptides from porcine brain. Decades of stroke, dementia, and TBI trial data — modest but consistent cognitive recovery effects.

Dihexa

C

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

Pinealon

C

A short tripeptide developed in Russia for cognitive aging and oxidative stress. Limited Western clinical evidence.

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