What is the difference between Dihexa and Selank?

Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). Selank (Selank (TP-7)) is graded B and is Not FDA-approved in US — approved in Russia as anxiolytic. They are commonly compared because they share the categories: cognitive.

Which has stronger clinical evidence — Dihexa or Selank?

On our internal evidence scale, Dihexa is C and Selank is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Dihexa vs Selank?

Dihexa: 8–45 mg orally daily (research-only). Selank: 200–400 mcg intranasal, evening. Always work with a licensed clinician — peptide dosing should be individualized.

Dihexa vs Selank

Both Dihexa and Selank are used for cognitive. Here's how their evidence, dosing, and regulatory status actually compare.

Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

View full Dihexa profile →

Selank

Evidence B

Selank (TP-7)

A synthetic analog of tuftsin with anxiolytic and nootropic properties. Modulates GABA and serotonin systems to reduce anxiety without sedation.

View full Selank profile →

Side-by-Side

Attribute	Dihexa	Selank
Evidence Grade	C	B
FDA Status	Not FDA-approved — research compound (HGF/c-Met-mimetic)	Not FDA-approved in US — approved in Russia as anxiolytic
Typical Dose	8–45 mg orally daily (research-only)	200–400 mcg intranasal, evening
Clinics Indexed	10	72
Categories	cognitive, neuroprotection	cognitive, anxiety

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Key reported benefits — Selank

✓Anxiety reduction
✓Stress resilience
✓Cognitive clarity
✓Immune modulation

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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