VIP: Benefits, Dosage & FDA Status
Vasoactive Intestinal Peptide
A 28-amino-acid neuropeptide with broad immunomodulatory effects. Used clinically (intranasal) by some practitioners for chronic inflammatory response syndrome (CIRS).
FDA Status
Not FDA-approved — investigational; ongoing trials for sarcoidosis
Typical Dose
50 mcg intranasal, 4 times daily (CIRS protocols)
Evidence Grade
BLimited clinical + robust preclinical evidence
Half-Life
~2 minutes (parenteral); local intranasal half-life longer
Routes of Administration
intranasal, intravenous
First Synthesized
1970
Clinics Indexed
24 providers have offered VIP in our tracked directory.
Mechanism of Action
Activates VPAC1/VPAC2 receptors; broadly anti-inflammatory and bronchodilatory.
Key Reported Benefits
- ✓Anti-inflammation
- ✓Pulmonary effects
- ✓Neuroprotection
Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade B indicates limited clinical + robust preclinical evidence.
Reported Side Effects
- •Hypotension at high doses
- •Flushing
Contraindications
- ⚠Severe hypotension
- ⚠Pregnancy
Regulatory & Safety Context
FDA status: Not FDA-approved — investigational; ongoing trials for sarcoidosis
This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.
See state-by-state legality: US peptide legality by state →
References
Selected primary literature on VIP. Full PubMed records linked. Additional citations are available on request.
Last reviewed: 2026-04-30
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