KPV: Benefits, Dosage & FDA Status
α-MSH Tripeptide KPV
The C-terminal tripeptide of α-MSH with documented anti-inflammatory activity in IBD and dermatitis preclinical models. Frequently delivered orally and topically.
FDA Status
Not FDA-approved — research peptide
Typical Dose
200–500 mcg orally or topical (research only)
Evidence Grade
C+Preclinical evidence + anecdotal clinical use
Half-Life
Minutes
Routes of Administration
oral, topical, subcutaneous
First Synthesized
1980s
Clinics Indexed
26 providers have offered KPV in our tracked directory.
Mechanism of Action
Tripeptide fragment of α-MSH that downregulates NF-κB signaling and pro-inflammatory cytokines.
Key Reported Benefits
- ✓GI inflammation reduction
- ✓Skin inflammation reduction
- ✓Antimicrobial activity
Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade C+ indicates preclinical evidence + anecdotal clinical use.
Reported Side Effects
- •Generally well-tolerated
Contraindications
- ⚠Pregnancy
Commonly Stacked With
Regulatory & Safety Context
FDA status: Not FDA-approved — research peptide
This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.
See state-by-state legality: US peptide legality by state →
References
Selected primary literature on KPV. Full PubMed records linked. Additional citations are available on request.
Last reviewed: 2026-04-30
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