What is the difference between Tesamorelin and Sermorelin?

Tesamorelin (Tesamorelin (Egrifta)) is graded A and is FDA-approved for HIV-associated lipodystrophy. Sermorelin (Sermorelin Acetate (GHRH 1-29)) is graded B+ and is FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies. They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — Tesamorelin or Sermorelin?

On our internal evidence scale, Tesamorelin is A and Sermorelin is B+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Tesamorelin vs Sermorelin?

Tesamorelin: 2 mg daily (subcutaneous). Sermorelin: 200–500 mcg before bed (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Tesamorelin vs Sermorelin

Both Tesamorelin and Sermorelin are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

Tesamorelin

Evidence A

Tesamorelin (Egrifta)

An FDA-approved GHRH analog that stimulates natural growth hormone production. Clinically proven to reduce visceral adipose tissue and increasingly used off-label for body recomposition.

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Sermorelin

Evidence B+

Sermorelin Acetate (GHRH 1-29)

The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.

View full Sermorelin profile →

Side-by-Side

Attribute	Tesamorelin	Sermorelin
Evidence Grade	A	B+
FDA Status	FDA-approved for HIV-associated lipodystrophy	FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies
Typical Dose	2 mg daily (subcutaneous)	200–500 mcg before bed (subcutaneous)
Clinics Indexed	178	220
Categories	growth-hormone, fat-loss	growth-hormone, anti-aging

Key reported benefits — Tesamorelin

✓Visceral fat reduction
✓Natural GH stimulation
✓Cognitive benefit
✓Lean mass

Key reported benefits — Sermorelin

✓Natural GH release
✓Improved sleep
✓Lean body mass
✓Recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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