What is the difference between Sermorelin and Hexarelin?

Sermorelin (Sermorelin Acetate (GHRH 1-29)) is graded B+ and is FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies. Hexarelin (Hexarelin (HEX)) is graded B and is Not FDA-approved — research compound (cardioprotective signals investigated). They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — Sermorelin or Hexarelin?

On our internal evidence scale, Sermorelin is B+ and Hexarelin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Sermorelin vs Hexarelin?

Sermorelin: 200–500 mcg before bed (subcutaneous). Hexarelin: 100 mcg, 1–2 times daily (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Sermorelin vs Hexarelin

Both Sermorelin and Hexarelin are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

Sermorelin

Evidence B+

Sermorelin Acetate (GHRH 1-29)

The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.

View full Sermorelin profile →

Hexarelin

Evidence B

Hexarelin (HEX)

The strongest GH-releasing hexapeptide and one of the few peptides with documented direct cardiac benefits in animal models. Tachyphylaxis (diminished response over time) limits long-term use.

View full Hexarelin profile →

Side-by-Side

Attribute	Sermorelin	Hexarelin
Evidence Grade	B+	B
FDA Status	FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies	Not FDA-approved — research compound (cardioprotective signals investigated)
Typical Dose	200–500 mcg before bed (subcutaneous)	100 mcg, 1–2 times daily (subcutaneous)
Clinics Indexed	220	41
Categories	growth-hormone, anti-aging	growth-hormone, recovery

Key reported benefits — Sermorelin

✓Natural GH release
✓Improved sleep
✓Lean body mass
✓Recovery

Key reported benefits — Hexarelin

✓Strongest GH spike of GHRPs
✓Cardioprotective signals
✓Recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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