Sermorelin vs GHRP-6
Both Sermorelin and GHRP-6 are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.
Sermorelin
Evidence B+Sermorelin Acetate (GHRH 1-29)
The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.
View full Sermorelin profile →GHRP-6
Evidence BGrowth Hormone Releasing Peptide 6
An older GHS that produces strong appetite stimulation in addition to GH release. Largely supplanted by Ipamorelin and GHRP-2 for clinical use but still common in research stacks.
View full GHRP-6 profile →Side-by-Side
| Attribute | Sermorelin | GHRP-6 |
|---|---|---|
| Evidence Grade | B+ | B |
| FDA Status | FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies | Not FDA-approved — research compound |
| Typical Dose | 200–500 mcg before bed (subcutaneous) | 100–300 mcg, 1–3 times daily (subcutaneous) |
| Clinics Indexed | 220 | 64 |
| Categories | growth-hormone, anti-aging | growth-hormone, appetite |
Key reported benefits — Sermorelin
- ✓Natural GH release
- ✓Improved sleep
- ✓Lean body mass
- ✓Recovery
Key reported benefits — GHRP-6
- ✓GH release
- ✓Appetite stimulation
- ✓Cytoprotection
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.