Sermorelin vs Epitalon
Both Sermorelin and Epitalon are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.
Sermorelin
Evidence B+Sermorelin Acetate (GHRH 1-29)
The original synthetic GHRH(1–29) and the most accessible GH-stimulating peptide for age-related hormone decline. Stimulates the body's own pulsatile GH release rather than replacing it.
View full Sermorelin profile →Epitalon
Evidence C+Epitalon (Epithalon, AEDG)
A synthetic tetrapeptide that reportedly upregulates telomerase activity. Russian longevity studies suggest mortality reductions but Western RCTs are absent.
View full Epitalon profile →Side-by-Side
| Attribute | Sermorelin | Epitalon |
|---|---|---|
| Evidence Grade | B+ | C+ |
| FDA Status | FDA-approved (1990) for pediatric growth hormone deficiency; off-label adult use via compounding pharmacies | Not FDA-approved — Russian-origin research peptide |
| Typical Dose | 200–500 mcg before bed (subcutaneous) | 5–10 mg daily for 10–20 days, cycled (subcutaneous) |
| Clinics Indexed | 220 | 47 |
| Categories | growth-hormone, anti-aging | anti-aging, longevity |
Key reported benefits — Sermorelin
- ✓Natural GH release
- ✓Improved sleep
- ✓Lean body mass
- ✓Recovery
Key reported benefits — Epitalon
- ✓Telomerase upregulation (preclinical)
- ✓Sleep/circadian normalization
- ✓Anti-aging signals
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.