What is the difference between Semax and DSIP?

Semax (Semax (MEHFPGP)) is graded B and is Not FDA-approved in US — approved in Russia for stroke and cognitive disorders. DSIP (Delta Sleep-Inducing Peptide) is graded C and is Not FDA-approved — research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — Semax or DSIP?

On our internal evidence scale, Semax is B and DSIP is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Semax vs DSIP?

Semax: 200–600 mcg intranasal, morning. DSIP: 100–300 mcg before bed (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Semax vs DSIP

Both Semax and DSIP are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Semax

Evidence B

Semax (MEHFPGP)

A synthetic ACTH fragment that increases BDNF levels and enhances focus, memory, and mental clarity. Delivered intranasally for rapid cognitive effects.

View full Semax profile →

DSIP

Evidence C

Delta Sleep-Inducing Peptide

A nonapeptide originally isolated from rabbit blood after EEG-defined slow-wave sleep induction. Inconsistent human evidence for sleep but explored for stress and analgesia.

View full DSIP profile →

Side-by-Side

Attribute	Semax	DSIP
Evidence Grade	B	C
FDA Status	Not FDA-approved in US — approved in Russia for stroke and cognitive disorders	Not FDA-approved — research compound
Typical Dose	200–600 mcg intranasal, morning	100–300 mcg before bed (subcutaneous)
Clinics Indexed	89	38
Categories	cognitive, neuroprotection	sleep, neuroprotection

Key reported benefits — Semax

✓BDNF increase
✓Enhanced focus
✓Memory improvement
✓Neuroprotection

Key reported benefits — DSIP

✓Slow-wave-sleep signals (preclinical)
✓Stress/cortisol modulation
✓Possible analgesic effect

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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