What is the difference between Semax and Cerebrolysin?

Semax (Semax (MEHFPGP)) is graded B and is Not FDA-approved in US — approved in Russia for stroke and cognitive disorders. Cerebrolysin (Cerebrolysin (porcine brain peptide complex)) is graded B and is Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia. They are commonly compared because they share the categories: cognitive, neuroprotection.

Which has stronger clinical evidence — Semax or Cerebrolysin?

On our internal evidence scale, Semax is B and Cerebrolysin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Semax vs Cerebrolysin?

Semax: 200–600 mcg intranasal, morning. Cerebrolysin: Trial range: 5–30 mL daily (intravenous infusion). Always work with a licensed clinician — peptide dosing should be individualized.

Semax vs Cerebrolysin

Both Semax and Cerebrolysin are used for cognitive and neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Semax

Evidence B

Semax (MEHFPGP)

A synthetic ACTH fragment that increases BDNF levels and enhances focus, memory, and mental clarity. Delivered intranasally for rapid cognitive effects.

View full Semax profile →

Cerebrolysin

Evidence B

Cerebrolysin (porcine brain peptide complex)

A standardized mixture of low-molecular-weight peptides from porcine brain. Decades of stroke, dementia, and TBI trial data — modest but consistent cognitive recovery effects.

View full Cerebrolysin profile →

Side-by-Side

Attribute	Semax	Cerebrolysin
Evidence Grade	B	B
FDA Status	Not FDA-approved in US — approved in Russia for stroke and cognitive disorders	Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia
Typical Dose	200–600 mcg intranasal, morning	Trial range: 5–30 mL daily (intravenous infusion)
Clinics Indexed	89	41
Categories	cognitive, neuroprotection	cognitive, neuroprotection

Key reported benefits — Semax

✓BDNF increase
✓Enhanced focus
✓Memory improvement
✓Neuroprotection

Key reported benefits — Cerebrolysin

✓Stroke recovery support
✓TBI rehabilitation
✓Cognitive function in dementia

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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