Selank vs Dihexa
Both Selank and Dihexa are used for cognitive. Here's how their evidence, dosing, and regulatory status actually compare.
Selank
Evidence BSelank (TP-7)
A synthetic analog of tuftsin with anxiolytic and nootropic properties. Modulates GABA and serotonin systems to reduce anxiety without sedation.
View full Selank profile →Dihexa
Evidence CDihexa (PNB-0408)
An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.
View full Dihexa profile →Side-by-Side
| Attribute | Selank | Dihexa |
|---|---|---|
| Evidence Grade | B | C |
| FDA Status | Not FDA-approved in US — approved in Russia as anxiolytic | Not FDA-approved — research compound (HGF/c-Met-mimetic) |
| Typical Dose | 200–400 mcg intranasal, evening | 8–45 mg orally daily (research-only) |
| Clinics Indexed | 72 | 10 |
| Categories | cognitive, anxiety | cognitive, neuroprotection |
Key reported benefits — Selank
- ✓Anxiety reduction
- ✓Stress resilience
- ✓Cognitive clarity
- ✓Immune modulation
Key reported benefits — Dihexa
- ✓Synaptogenesis (preclinical)
- ✓Memory improvement (animal)
- ✓Possible Alzheimer's relevance
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.