What is the difference between MOTS-c and SS-31?

MOTS-c (Mitochondrial-derived peptide MOTS-c) is graded B and is Not FDA-approved — research peptide; multiple early-phase clinical trials. SS-31 (Elamipretide (SS-31)) is graded B+ and is Not FDA-approved — Phase 3 trials for primary mitochondrial myopathy. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — MOTS-c or SS-31?

On our internal evidence scale, MOTS-c is B and SS-31 is B+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of MOTS-c vs SS-31?

MOTS-c: 5–10 mg, 2–3 times weekly (subcutaneous). SS-31: Trial range: 40 mg subcutaneous daily. Always work with a licensed clinician — peptide dosing should be individualized.

MOTS-c vs SS-31

Both MOTS-c and SS-31 are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

MOTS-c

Evidence B

Mitochondrial-derived peptide MOTS-c

A 16-amino-acid mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity in animal models. Among the most promising 'mitokines' for metabolic aging.

View full MOTS-c profile →

SS-31

Evidence B+

Elamipretide (SS-31)

A cell-permeable tetrapeptide that targets cardiolipin in the inner mitochondrial membrane. Investigated for primary mitochondrial myopathy, heart failure, and dry age-related macular degeneration.

View full SS-31 profile →

Side-by-Side

Attribute	MOTS-c	SS-31
Evidence Grade	B	B+
FDA Status	Not FDA-approved — research peptide; multiple early-phase clinical trials	Not FDA-approved — Phase 3 trials for primary mitochondrial myopathy
Typical Dose	5–10 mg, 2–3 times weekly (subcutaneous)	Trial range: 40 mg subcutaneous daily
Clinics Indexed	22	29
Categories	metabolic, longevity	mitochondrial, longevity

Key reported benefits — MOTS-c

✓Insulin sensitivity
✓Exercise capacity
✓Metabolic flexibility

Key reported benefits — SS-31

✓Mitochondrial cardiolipin support
✓ATP production
✓Reduced oxidative damage

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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