What is the difference between Humanin and SS-31?

Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. SS-31 (Elamipretide (SS-31)) is graded B+ and is Not FDA-approved — Phase 3 trials for primary mitochondrial myopathy. They are commonly compared because they share the categories: mitochondrial, longevity.

Which has stronger clinical evidence — Humanin or SS-31?

On our internal evidence scale, Humanin is B and SS-31 is B+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Humanin vs SS-31?

Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). SS-31: Trial range: 40 mg subcutaneous daily. Always work with a licensed clinician — peptide dosing should be individualized.

Humanin vs SS-31

Both Humanin and SS-31 are used for mitochondrial and longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

SS-31

Evidence B+

Elamipretide (SS-31)

A cell-permeable tetrapeptide that targets cardiolipin in the inner mitochondrial membrane. Investigated for primary mitochondrial myopathy, heart failure, and dry age-related macular degeneration.

View full SS-31 profile →

Side-by-Side

Attribute	Humanin	SS-31
Evidence Grade	B	B+
FDA Status	Not FDA-approved — mitochondrial-derived peptide research compound	Not FDA-approved — Phase 3 trials for primary mitochondrial myopathy
Typical Dose	Research range: 0.5–1 mg subcutaneous (rare clinical use)	Trial range: 40 mg subcutaneous daily
Clinics Indexed	5	29
Categories	mitochondrial, longevity, neuroprotection	mitochondrial, longevity

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Key reported benefits — SS-31

✓Mitochondrial cardiolipin support
✓ATP production
✓Reduced oxidative damage

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons