What is the difference between Humanin and Semax?

Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. Semax (Semax (MEHFPGP)) is graded B and is Not FDA-approved in US — approved in Russia for stroke and cognitive disorders. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — Humanin or Semax?

On our internal evidence scale, Humanin is B and Semax is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Humanin vs Semax?

Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Semax: 200–600 mcg intranasal, morning. Always work with a licensed clinician — peptide dosing should be individualized.

Humanin vs Semax

Both Humanin and Semax are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

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Semax

Evidence B

Semax (MEHFPGP)

A synthetic ACTH fragment that increases BDNF levels and enhances focus, memory, and mental clarity. Delivered intranasally for rapid cognitive effects.

View full Semax profile →

Side-by-Side

Attribute	Humanin	Semax
Evidence Grade	B	B
FDA Status	Not FDA-approved — mitochondrial-derived peptide research compound	Not FDA-approved in US — approved in Russia for stroke and cognitive disorders
Typical Dose	Research range: 0.5–1 mg subcutaneous (rare clinical use)	200–600 mcg intranasal, morning
Clinics Indexed	5	89
Categories	mitochondrial, longevity, neuroprotection	cognitive, neuroprotection

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Key reported benefits — Semax

✓BDNF increase
✓Enhanced focus
✓Memory improvement
✓Neuroprotection

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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