Survodutide: Benefits, Dosage & FDA Status
Survodutide (BI 456906)
A dual GLP-1 / glucagon receptor agonist with strong Phase 2 weight-loss and MASH data. Resolution of MASH in 83% of participants at the highest dose at week 48.
FDA Status
Not FDA-approved — Phase 3 trials for obesity and MASH
Typical Dose
Trial range: 0.6–6 mg weekly (subcutaneous)
Evidence Grade
AStrong RCT or FDA-approved evidence
Half-Life
~6 days
Routes of Administration
subcutaneous
First Synthesized
2020
Clinics Indexed
6 providers have offered Survodutide in our tracked directory.
Mechanism of Action
Dual GLP-1 / glucagon receptor agonist; combines incretin appetite control with glucagon-driven energy expenditure and hepatic fat reduction.
Key Reported Benefits
- ✓Weight loss
- ✓MASH resolution
- ✓Glucose control
Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade A indicates strong rct or fda-approved evidence.
Reported Side Effects
- •Nausea
- •Vomiting
- •GI symptoms
Contraindications
- ⚠Personal/family history of medullary thyroid carcinoma
- ⚠Pregnancy
Regulatory & Safety Context
FDA status: Not FDA-approved — Phase 3 trials for obesity and MASH
This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.
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References
Selected primary literature on Survodutide. Full PubMed records linked. Additional citations are available on request.
Last reviewed: 2026-04-30
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