Gonadorelin: Benefits, Dosage & FDA Status
Gonadorelin (GnRH)
Synthetic GnRH used clinically to stimulate LH/FSH release. In testosterone replacement therapy, used pulsatile to preserve testicular size and fertility instead of hCG.
FDA Status
FDA-approved (Factrel) historically for diagnostic GnRH stimulation; off-label use in TRT to preserve testicular function
Typical Dose
100–500 mcg every 1–3 days (subcutaneous, pulsatile)
Evidence Grade
AStrong RCT or FDA-approved evidence
Half-Life
~5 minutes
Routes of Administration
subcutaneous
First Synthesized
1971
Clinics Indexed
156 providers have offered Gonadorelin in our tracked directory.
Mechanism of Action
Decapeptide identical to endogenous GnRH; pulsatile dosing drives LH/FSH release without HPG-axis desensitization.
Key Reported Benefits
- ✓LH/FSH stimulation
- ✓Testicular preservation on TRT
- ✓Fertility support
Benefits listed reflect commonly reported effects from clinical trials and practitioner use. Individual response varies. Evidence-grade A indicates strong rct or fda-approved evidence.
Reported Side Effects
- •Injection-site reactions
- •Headache (rare)
Contraindications
- ⚠Hormone-sensitive cancers
- ⚠Pregnancy
Gonadorelin vs Other Peptides
Regulatory & Safety Context
FDA status: FDA-approved (Factrel) historically for diagnostic GnRH stimulation; off-label use in TRT to preserve testicular function
This page is for educational purposes only and does not constitute medical advice. Peptide use outside of an FDA-approved indication should be discussed with a licensed medical professional. Source quality, cold-chain storage, and injection hygiene all materially affect safety outcomes.
See state-by-state legality: US peptide legality by state →
References
Selected primary literature on Gonadorelin. Full PubMed records linked. Additional citations are available on request.
Last reviewed: 2026-04-30
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