What is the difference between Tesamorelin and Hexarelin?

Tesamorelin (Tesamorelin (Egrifta)) is graded A and is FDA-approved for HIV-associated lipodystrophy. Hexarelin (Hexarelin (HEX)) is graded B and is Not FDA-approved — research compound (cardioprotective signals investigated). They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — Tesamorelin or Hexarelin?

On our internal evidence scale, Tesamorelin is A and Hexarelin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Tesamorelin vs Hexarelin?

Tesamorelin: 2 mg daily (subcutaneous). Hexarelin: 100 mcg, 1–2 times daily (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Tesamorelin vs Hexarelin

Both Tesamorelin and Hexarelin are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

Tesamorelin

Evidence A

Tesamorelin (Egrifta)

An FDA-approved GHRH analog that stimulates natural growth hormone production. Clinically proven to reduce visceral adipose tissue and increasingly used off-label for body recomposition.

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Hexarelin

Evidence B

Hexarelin (HEX)

The strongest GH-releasing hexapeptide and one of the few peptides with documented direct cardiac benefits in animal models. Tachyphylaxis (diminished response over time) limits long-term use.

View full Hexarelin profile →

Side-by-Side

Attribute	Tesamorelin	Hexarelin
Evidence Grade	A	B
FDA Status	FDA-approved for HIV-associated lipodystrophy	Not FDA-approved — research compound (cardioprotective signals investigated)
Typical Dose	2 mg daily (subcutaneous)	100 mcg, 1–2 times daily (subcutaneous)
Clinics Indexed	178	41
Categories	growth-hormone, fat-loss	growth-hormone, recovery

Key reported benefits — Tesamorelin

✓Visceral fat reduction
✓Natural GH stimulation
✓Cognitive benefit
✓Lean mass

Key reported benefits — Hexarelin

✓Strongest GH spike of GHRPs
✓Cardioprotective signals
✓Recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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