What is the difference between Tesamorelin and GHRP-2?

Tesamorelin (Tesamorelin (Egrifta)) is graded A and is FDA-approved for HIV-associated lipodystrophy. GHRP-2 (Growth Hormone Releasing Peptide 2) is graded B and is Not FDA-approved — research compound; previously studied as growth hormone deficiency diagnostic. They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — Tesamorelin or GHRP-2?

On our internal evidence scale, Tesamorelin is A and GHRP-2 is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Tesamorelin vs GHRP-2?

Tesamorelin: 2 mg daily (subcutaneous). GHRP-2: 100–300 mcg, 1–3 times daily (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Tesamorelin vs GHRP-2

Both Tesamorelin and GHRP-2 are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

Tesamorelin

Evidence A

Tesamorelin (Egrifta)

An FDA-approved GHRH analog that stimulates natural growth hormone production. Clinically proven to reduce visceral adipose tissue and increasingly used off-label for body recomposition.

View full Tesamorelin profile →

GHRP-2

Evidence B

Growth Hormone Releasing Peptide 2

A potent synthetic ghrelin-mimetic GH secretagogue. Drives strong GH spikes but raises cortisol and prolactin more than newer alternatives like Ipamorelin.

View full GHRP-2 profile →

Side-by-Side

Attribute	Tesamorelin	GHRP-2
Evidence Grade	A	B
FDA Status	FDA-approved for HIV-associated lipodystrophy	Not FDA-approved — research compound; previously studied as growth hormone deficiency diagnostic
Typical Dose	2 mg daily (subcutaneous)	100–300 mcg, 1–3 times daily (subcutaneous)
Clinics Indexed	178	86
Categories	growth-hormone, fat-loss	growth-hormone, anti-aging

Key reported benefits — Tesamorelin

✓Visceral fat reduction
✓Natural GH stimulation
✓Cognitive benefit
✓Lean mass

Key reported benefits — GHRP-2

✓Strong GH release
✓Appetite stimulation
✓Muscle recovery

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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