What is the difference between Tesamorelin and GHRH (1–44)?

Tesamorelin (Tesamorelin (Egrifta)) is graded A and is FDA-approved for HIV-associated lipodystrophy. GHRH (1–44) (Growth Hormone Releasing Hormone, full sequence) is graded A and is FDA-approved (Geref) historically as diagnostic GH stimulant; current US availability limited. They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — Tesamorelin or GHRH (1–44)?

On our internal evidence scale, Tesamorelin is A and GHRH (1–44) is A. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Tesamorelin vs GHRH (1–44)?

Tesamorelin: 2 mg daily (subcutaneous). GHRH (1–44): 1 mcg/kg IV (diagnostic test). Always work with a licensed clinician — peptide dosing should be individualized.

Tesamorelin vs GHRH (1–44)

Both Tesamorelin and GHRH (1–44) are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

Tesamorelin

Evidence A

Tesamorelin (Egrifta)

An FDA-approved GHRH analog that stimulates natural growth hormone production. Clinically proven to reduce visceral adipose tissue and increasingly used off-label for body recomposition.

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GHRH (1–44)

Evidence A

Growth Hormone Releasing Hormone, full sequence

The full 44-amino-acid GHRH sequence. The natural pituitary stimulus for GH release. Largely supplanted in clinical use by sermorelin/tesamorelin but remains a research and diagnostic tool.

View full GHRH (1–44) profile →

Side-by-Side

Attribute	Tesamorelin	GHRH (1–44)
Evidence Grade	A	A
FDA Status	FDA-approved for HIV-associated lipodystrophy	FDA-approved (Geref) historically as diagnostic GH stimulant; current US availability limited
Typical Dose	2 mg daily (subcutaneous)	1 mcg/kg IV (diagnostic test)
Clinics Indexed	178	22
Categories	growth-hormone, fat-loss	growth-hormone

Key reported benefits — Tesamorelin

✓Visceral fat reduction
✓Natural GH stimulation
✓Cognitive benefit
✓Lean mass

Key reported benefits — GHRH (1–44)

✓Endogenous GH stimulation
✓Diagnostic GH testing

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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