What is the difference between Semaglutide and Cagrilintide?

Semaglutide (Semaglutide (Ozempic / Wegovy)) is graded A+ and is FDA-approved for weight management and type 2 diabetes. Cagrilintide (Cagrilintide (long-acting amylin analog)) is graded A and is Not FDA-approved — combined with semaglutide as CagriSema; Phase 3 in progress. They are commonly compared because they share the categories: weight-loss, metabolic.

Which has stronger clinical evidence — Semaglutide or Cagrilintide?

On our internal evidence scale, Semaglutide is A+ and Cagrilintide is A. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Semaglutide vs Cagrilintide?

Semaglutide: 0.25–2.4 mg weekly (subcutaneous injection). Cagrilintide: Trial range: 0.16–4.5 mg weekly (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Semaglutide vs Cagrilintide

Both Semaglutide and Cagrilintide are used for weight-loss and metabolic. Here's how their evidence, dosing, and regulatory status actually compare.

Semaglutide

Evidence A+

Semaglutide (Ozempic / Wegovy)

A GLP-1 receptor agonist and the gold standard for evidence-based weight loss peptide therapy. Demonstrated 14.9–16.9% mean body weight reduction in the landmark STEP trials.

View full Semaglutide profile →

Cagrilintide

Evidence A

Cagrilintide (long-acting amylin analog)

A once-weekly amylin analog that reduces appetite via the area postrema. Combined with semaglutide ('CagriSema') it has produced ~22% weight loss in trial data.

View full Cagrilintide profile →

Side-by-Side

Attribute	Semaglutide	Cagrilintide
Evidence Grade	A+	A
FDA Status	FDA-approved for weight management and type 2 diabetes	Not FDA-approved — combined with semaglutide as CagriSema; Phase 3 in progress
Typical Dose	0.25–2.4 mg weekly (subcutaneous injection)	Trial range: 0.16–4.5 mg weekly (subcutaneous)
Clinics Indexed	2,285	8
Categories	weight-loss, metabolic	weight-loss, metabolic

Key reported benefits — Semaglutide

✓Significant weight loss
✓Appetite suppression
✓Blood sugar control
✓Cardiovascular benefit

Key reported benefits — Cagrilintide

✓Amylin pathway weight loss
✓Synergy with GLP-1
✓Lower-dose tolerability

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons