What is the difference between Retatrutide and Semaglutide?

Retatrutide (Retatrutide (LY3437943)) is graded A and is Not FDA-approved — Phase 3 trials (TRIUMPH program) for obesity. Semaglutide (Semaglutide (Ozempic / Wegovy)) is graded A+ and is FDA-approved for weight management and type 2 diabetes. They are commonly compared because they share the categories: weight-loss, metabolic.

Which has stronger clinical evidence — Retatrutide or Semaglutide?

On our internal evidence scale, Retatrutide is A and Semaglutide is A+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Retatrutide vs Semaglutide?

Retatrutide: Trial range: 1–12 mg weekly (subcutaneous). Semaglutide: 0.25–2.4 mg weekly (subcutaneous injection). Always work with a licensed clinician — peptide dosing should be individualized.

Retatrutide vs Semaglutide

Both Retatrutide and Semaglutide are used for weight-loss and metabolic. Here's how their evidence, dosing, and regulatory status actually compare.

Retatrutide

Evidence A

Retatrutide (LY3437943)

Triple agonist at GLP-1, GIP, and glucagon receptors. Phase 2 produced 24.2% mean weight reduction at 48 weeks — the highest ever in a clinical obesity trial.

View full Retatrutide profile →

Semaglutide

Evidence A+

Semaglutide (Ozempic / Wegovy)

A GLP-1 receptor agonist and the gold standard for evidence-based weight loss peptide therapy. Demonstrated 14.9–16.9% mean body weight reduction in the landmark STEP trials.

View full Semaglutide profile →

Side-by-Side

Attribute	Retatrutide	Semaglutide
Evidence Grade	A	A+
FDA Status	Not FDA-approved — Phase 3 trials (TRIUMPH program) for obesity	FDA-approved for weight management and type 2 diabetes
Typical Dose	Trial range: 1–12 mg weekly (subcutaneous)	0.25–2.4 mg weekly (subcutaneous injection)
Clinics Indexed	12	2,285
Categories	weight-loss, metabolic	weight-loss, metabolic

Key reported benefits — Retatrutide

✓Highest reported weight loss
✓Triple incretin/glucagon mechanism
✓Metabolic improvement

Key reported benefits — Semaglutide

✓Significant weight loss
✓Appetite suppression
✓Blood sugar control
✓Cardiovascular benefit

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons