What is the difference between Pinealon and Humanin?

Pinealon (Pinealon (EDR)) is graded C and is Not FDA-approved — Russian-origin research peptide. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Pinealon or Humanin?

On our internal evidence scale, Pinealon is C and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Pinealon vs Humanin?

Pinealon: 5–10 mg daily for 10–20 days (subcutaneous, cycled). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

Pinealon vs Humanin

Both Pinealon and Humanin are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Pinealon

Evidence C

Pinealon (EDR)

A short tripeptide developed in Russia for cognitive aging and oxidative stress. Limited Western clinical evidence.

View full Pinealon profile →

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	Pinealon	Humanin
Evidence Grade	C	B
FDA Status	Not FDA-approved — Russian-origin research peptide	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	5–10 mg daily for 10–20 days (subcutaneous, cycled)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	9	5
Categories	cognitive, longevity	mitochondrial, longevity, neuroprotection

Key reported benefits — Pinealon

✓Cognitive function (preclinical)
✓Reduced oxidative damage
✓Sleep/circadian effects

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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