What is the difference between MOTS-c and Pinealon?

MOTS-c (Mitochondrial-derived peptide MOTS-c) is graded B and is Not FDA-approved — research peptide; multiple early-phase clinical trials. Pinealon (Pinealon (EDR)) is graded C and is Not FDA-approved — Russian-origin research peptide. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — MOTS-c or Pinealon?

On our internal evidence scale, MOTS-c is B and Pinealon is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of MOTS-c vs Pinealon?

MOTS-c: 5–10 mg, 2–3 times weekly (subcutaneous). Pinealon: 5–10 mg daily for 10–20 days (subcutaneous, cycled). Always work with a licensed clinician — peptide dosing should be individualized.

MOTS-c vs Pinealon

Both MOTS-c and Pinealon are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

MOTS-c

Evidence B

Mitochondrial-derived peptide MOTS-c

A 16-amino-acid mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity in animal models. Among the most promising 'mitokines' for metabolic aging.

View full MOTS-c profile →

Pinealon

Evidence C

Pinealon (EDR)

A short tripeptide developed in Russia for cognitive aging and oxidative stress. Limited Western clinical evidence.

View full Pinealon profile →

Side-by-Side

Attribute	MOTS-c	Pinealon
Evidence Grade	B	C
FDA Status	Not FDA-approved — research peptide; multiple early-phase clinical trials	Not FDA-approved — Russian-origin research peptide
Typical Dose	5–10 mg, 2–3 times weekly (subcutaneous)	5–10 mg daily for 10–20 days (subcutaneous, cycled)
Clinics Indexed	22	9
Categories	metabolic, longevity	cognitive, longevity

Key reported benefits — MOTS-c

✓Insulin sensitivity
✓Exercise capacity
✓Metabolic flexibility

Key reported benefits — Pinealon

✓Cognitive function (preclinical)
✓Reduced oxidative damage
✓Sleep/circadian effects

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons