What is the difference between MOTS-c and Humanin?

MOTS-c (Mitochondrial-derived peptide MOTS-c) is graded B and is Not FDA-approved — research peptide; multiple early-phase clinical trials. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — MOTS-c or Humanin?

On our internal evidence scale, MOTS-c is B and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of MOTS-c vs Humanin?

MOTS-c: 5–10 mg, 2–3 times weekly (subcutaneous). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

MOTS-c vs Humanin

Both MOTS-c and Humanin are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

MOTS-c

Evidence B

Mitochondrial-derived peptide MOTS-c

A 16-amino-acid mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity in animal models. Among the most promising 'mitokines' for metabolic aging.

View full MOTS-c profile →

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	MOTS-c	Humanin
Evidence Grade	B	B
FDA Status	Not FDA-approved — research peptide; multiple early-phase clinical trials	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	5–10 mg, 2–3 times weekly (subcutaneous)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	22	5
Categories	metabolic, longevity	mitochondrial, longevity, neuroprotection

Key reported benefits — MOTS-c

✓Insulin sensitivity
✓Exercise capacity
✓Metabolic flexibility

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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