What is the difference between MK-677 and Tesamorelin?

MK-677 (Ibutamoren (MK-677)) is graded B+ and is Not FDA-approved — investigational (orally active GH secretagogue). Tesamorelin (Tesamorelin (Egrifta)) is graded A and is FDA-approved for HIV-associated lipodystrophy. They are commonly compared because they share the categories: growth-hormone.

Which has stronger clinical evidence — MK-677 or Tesamorelin?

On our internal evidence scale, MK-677 is B+ and Tesamorelin is A. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of MK-677 vs Tesamorelin?

MK-677: 10–25 mg orally, once daily. Tesamorelin: 2 mg daily (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

MK-677 vs Tesamorelin

Both MK-677 and Tesamorelin are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.

MK-677

Evidence B+

Ibutamoren (MK-677)

An orally active ghrelin-receptor agonist that drives 24-hour increases in GH and IGF-1. Technically a non-peptide small molecule but always grouped with GH peptides.

View full MK-677 profile →

Tesamorelin

Evidence A

Tesamorelin (Egrifta)

An FDA-approved GHRH analog that stimulates natural growth hormone production. Clinically proven to reduce visceral adipose tissue and increasingly used off-label for body recomposition.

View full Tesamorelin profile →

Side-by-Side

Attribute	MK-677	Tesamorelin
Evidence Grade	B+	A
FDA Status	Not FDA-approved — investigational (orally active GH secretagogue)	FDA-approved for HIV-associated lipodystrophy
Typical Dose	10–25 mg orally, once daily	2 mg daily (subcutaneous)
Clinics Indexed	165	178
Categories	growth-hormone, anti-aging	growth-hormone, fat-loss

Key reported benefits — MK-677

✓Sustained GH/IGF-1 elevation
✓Sleep depth
✓Lean mass
✓Bone density

Key reported benefits — Tesamorelin

✓Visceral fat reduction
✓Natural GH stimulation
✓Cognitive benefit
✓Lean mass

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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