Kisspeptin-10 vs Melanotan II
Both Kisspeptin-10 and Melanotan II are used for sexual-health. Here's how their evidence, dosing, and regulatory status actually compare.
Kisspeptin-10
Evidence BKisspeptin-10 (KP-10)
A 10-amino-acid neuropeptide that triggers GnRH release. Studied as a more physiologic alternative to hCG/GnRH for fertility, libido, and HPG-axis assessment.
View full Kisspeptin-10 profile →Melanotan II
Evidence C+Melanotan II (MT-II)
A non-selective melanocortin agonist (MC1R/MC3R/MC4R) that produces tanning and erection effects. Significant safety concerns including melanoma case reports.
View full Melanotan II profile →Side-by-Side
| Attribute | Kisspeptin-10 | Melanotan II |
|---|---|---|
| Evidence Grade | B | C+ |
| FDA Status | Not FDA-approved — used in clinical research as a kisspeptin/GnRH stimulus test | Not FDA-approved — sold illegally as cosmetic; FDA warning letters issued |
| Typical Dose | Trial range: 0.1–10 mcg/kg IV/SC bolus | 0.25–1 mg daily during loading, then maintenance (subcutaneous) |
| Clinics Indexed | 11 | 18 |
| Categories | sexual-health, fertility | skin, sexual-health |
Key reported benefits — Kisspeptin-10
- ✓GnRH/LH/FSH stimulation
- ✓Libido/arousal effects
- ✓HPG-axis testing
Key reported benefits — Melanotan II
- ✓UV-independent tanning
- ✓Erectile effect (off-label)
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.