What is the difference between Ipamorelin and Epitalon?

Ipamorelin (Ipamorelin Acetate) is graded B and is Not FDA-approved — Category 1 (compounding allowed). Epitalon (Epitalon (Epithalon, AEDG)) is graded C+ and is Not FDA-approved — Russian-origin research peptide. They are commonly compared because they share the categories: anti-aging.

Which has stronger clinical evidence — Ipamorelin or Epitalon?

On our internal evidence scale, Ipamorelin is B and Epitalon is C+. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Ipamorelin vs Epitalon?

Ipamorelin: 100–300 mcg before bed (subcutaneous). Epitalon: 5–10 mg daily for 10–20 days, cycled (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Ipamorelin vs Epitalon

Both Ipamorelin and Epitalon are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.

Ipamorelin

Evidence B

Ipamorelin Acetate

A selective growth hormone secretagogue that triggers GH release from the pituitary without significantly raising cortisol or prolactin. The safest GH peptide with the fewest side effects.

View full Ipamorelin profile →

Epitalon

Evidence C+

Epitalon (Epithalon, AEDG)

A synthetic tetrapeptide that reportedly upregulates telomerase activity. Russian longevity studies suggest mortality reductions but Western RCTs are absent.

View full Epitalon profile →

Side-by-Side

Attribute	Ipamorelin	Epitalon
Evidence Grade	B	C+
FDA Status	Not FDA-approved — Category 1 (compounding allowed)	Not FDA-approved — Russian-origin research peptide
Typical Dose	100–300 mcg before bed (subcutaneous)	5–10 mg daily for 10–20 days, cycled (subcutaneous)
Clinics Indexed	195	47
Categories	growth-hormone, anti-aging	anti-aging, longevity

Key reported benefits — Ipamorelin

✓Clean GH release
✓Improved sleep quality
✓Fat reduction
✓Joint health

Key reported benefits — Epitalon

✓Telomerase upregulation (preclinical)
✓Sleep/circadian normalization
✓Anti-aging signals

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons