What is the difference between Humanin and Pinealon?

Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. Pinealon (Pinealon (EDR)) is graded C and is Not FDA-approved — Russian-origin research peptide. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Humanin or Pinealon?

On our internal evidence scale, Humanin is B and Pinealon is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Humanin vs Pinealon?

Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Pinealon: 5–10 mg daily for 10–20 days (subcutaneous, cycled). Always work with a licensed clinician — peptide dosing should be individualized.

Humanin vs Pinealon

Both Humanin and Pinealon are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Pinealon

Evidence C

Pinealon (EDR)

A short tripeptide developed in Russia for cognitive aging and oxidative stress. Limited Western clinical evidence.

View full Pinealon profile →

Side-by-Side

Attribute	Humanin	Pinealon
Evidence Grade	B	C
FDA Status	Not FDA-approved — mitochondrial-derived peptide research compound	Not FDA-approved — Russian-origin research peptide
Typical Dose	Research range: 0.5–1 mg subcutaneous (rare clinical use)	5–10 mg daily for 10–20 days (subcutaneous, cycled)
Clinics Indexed	5	9
Categories	mitochondrial, longevity, neuroprotection	cognitive, longevity

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Key reported benefits — Pinealon

✓Cognitive function (preclinical)
✓Reduced oxidative damage
✓Sleep/circadian effects

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons