What is the difference between Humanin and Glutathione (GSH)?

Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. Glutathione (GSH) (Reduced L-Glutathione) is graded B and is Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Humanin or Glutathione (GSH)?

On our internal evidence scale, Humanin is B and Glutathione (GSH) is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Humanin vs Glutathione (GSH)?

Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Glutathione (GSH): 200–600 mg sublingual / 600–2400 mg IV (compounded). Always work with a licensed clinician — peptide dosing should be individualized.

Humanin vs Glutathione (GSH)

Both Humanin and Glutathione (GSH) are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

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Glutathione (GSH)

Evidence B

Reduced L-Glutathione

Technically a tripeptide (γ-glutamyl-cysteinyl-glycine) and the body's primary antioxidant. Often grouped with peptide therapy in IV/compounded form for liver support and oxidative stress.

View full Glutathione (GSH) profile →

Side-by-Side

Attribute	Humanin	Glutathione (GSH)
Evidence Grade	B	B
FDA Status	Not FDA-approved — mitochondrial-derived peptide research compound	Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded
Typical Dose	Research range: 0.5–1 mg subcutaneous (rare clinical use)	200–600 mg sublingual / 600–2400 mg IV (compounded)
Clinics Indexed	5	312
Categories	mitochondrial, longevity, neuroprotection	antioxidant, longevity

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Key reported benefits — Glutathione (GSH)

✓Master antioxidant
✓Liver detoxification support
✓Oxidative stress reduction

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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