Hexarelin vs Ipamorelin
Both Hexarelin and Ipamorelin are used for growth-hormone. Here's how their evidence, dosing, and regulatory status actually compare.
Hexarelin
Evidence BHexarelin (HEX)
The strongest GH-releasing hexapeptide and one of the few peptides with documented direct cardiac benefits in animal models. Tachyphylaxis (diminished response over time) limits long-term use.
View full Hexarelin profile →Ipamorelin
Evidence BIpamorelin Acetate
A selective growth hormone secretagogue that triggers GH release from the pituitary without significantly raising cortisol or prolactin. The safest GH peptide with the fewest side effects.
View full Ipamorelin profile →Side-by-Side
| Attribute | Hexarelin | Ipamorelin |
|---|---|---|
| Evidence Grade | B | B |
| FDA Status | Not FDA-approved — research compound (cardioprotective signals investigated) | Not FDA-approved — Category 1 (compounding allowed) |
| Typical Dose | 100 mcg, 1–2 times daily (subcutaneous) | 100–300 mcg before bed (subcutaneous) |
| Clinics Indexed | 41 | 195 |
| Categories | growth-hormone, recovery | growth-hormone, anti-aging |
Key reported benefits — Hexarelin
- ✓Strongest GH spike of GHRPs
- ✓Cardioprotective signals
- ✓Recovery
Key reported benefits — Ipamorelin
- ✓Clean GH release
- ✓Improved sleep quality
- ✓Fat reduction
- ✓Joint health
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.