What is the difference between Glutathione (GSH) and MOTS-c?

Glutathione (GSH) (Reduced L-Glutathione) is graded B and is Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded. MOTS-c (Mitochondrial-derived peptide MOTS-c) is graded B and is Not FDA-approved — research peptide; multiple early-phase clinical trials. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Glutathione (GSH) or MOTS-c?

On our internal evidence scale, Glutathione (GSH) is B and MOTS-c is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Glutathione (GSH) vs MOTS-c?

Glutathione (GSH): 200–600 mg sublingual / 600–2400 mg IV (compounded). MOTS-c: 5–10 mg, 2–3 times weekly (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Glutathione (GSH) vs MOTS-c

Both Glutathione (GSH) and MOTS-c are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Glutathione (GSH)

Evidence B

Reduced L-Glutathione

Technically a tripeptide (γ-glutamyl-cysteinyl-glycine) and the body's primary antioxidant. Often grouped with peptide therapy in IV/compounded form for liver support and oxidative stress.

View full Glutathione (GSH) profile →

MOTS-c

Evidence B

Mitochondrial-derived peptide MOTS-c

A 16-amino-acid mitochondrial-derived peptide that improves insulin sensitivity and exercise capacity in animal models. Among the most promising 'mitokines' for metabolic aging.

View full MOTS-c profile →

Side-by-Side

Attribute	Glutathione (GSH)	MOTS-c
Evidence Grade	B	B
FDA Status	Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded	Not FDA-approved — research peptide; multiple early-phase clinical trials
Typical Dose	200–600 mg sublingual / 600–2400 mg IV (compounded)	5–10 mg, 2–3 times weekly (subcutaneous)
Clinics Indexed	312	22
Categories	antioxidant, longevity	metabolic, longevity

Key reported benefits — Glutathione (GSH)

✓Master antioxidant
✓Liver detoxification support
✓Oxidative stress reduction

Key reported benefits — MOTS-c

✓Insulin sensitivity
✓Exercise capacity
✓Metabolic flexibility

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons