What is the difference between Glutathione (GSH) and Humanin?

Glutathione (GSH) (Reduced L-Glutathione) is graded B and is Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Glutathione (GSH) or Humanin?

On our internal evidence scale, Glutathione (GSH) is B and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Glutathione (GSH) vs Humanin?

Glutathione (GSH): 200–600 mg sublingual / 600–2400 mg IV (compounded). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

Glutathione (GSH) vs Humanin

Both Glutathione (GSH) and Humanin are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Glutathione (GSH)

Evidence B

Reduced L-Glutathione

Technically a tripeptide (γ-glutamyl-cysteinyl-glycine) and the body's primary antioxidant. Often grouped with peptide therapy in IV/compounded form for liver support and oxidative stress.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	Glutathione (GSH)	Humanin
Evidence Grade	B	B
FDA Status	Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	200–600 mg sublingual / 600–2400 mg IV (compounded)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	312	5
Categories	antioxidant, longevity	mitochondrial, longevity, neuroprotection

Key reported benefits — Glutathione (GSH)

✓Master antioxidant
✓Liver detoxification support
✓Oxidative stress reduction

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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