GHK-Cu vs MK-677
Both GHK-Cu and MK-677 are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.
GHK-Cu
Evidence B+Copper Peptide GHK-Cu
A naturally occurring copper-binding tripeptide that modulates 4,000+ human genes. The most studied peptide for skin rejuvenation with both preclinical and clinical topical evidence.
View full GHK-Cu profile →MK-677
Evidence B+Ibutamoren (MK-677)
An orally active ghrelin-receptor agonist that drives 24-hour increases in GH and IGF-1. Technically a non-peptide small molecule but always grouped with GH peptides.
View full MK-677 profile →Side-by-Side
| Attribute | GHK-Cu | MK-677 |
|---|---|---|
| Evidence Grade | B+ | B+ |
| FDA Status | Not FDA-approved — available as cosmetic ingredient and research compound | Not FDA-approved — investigational (orally active GH secretagogue) |
| Typical Dose | 1–2 mg daily SC or topical (5 days on / 2 off) | 10–25 mg orally, once daily |
| Clinics Indexed | 145 | 165 |
| Categories | anti-aging, skin, hair | growth-hormone, anti-aging |
Key reported benefits — GHK-Cu
- ✓Collagen synthesis
- ✓Wrinkle reduction
- ✓Hair growth
- ✓Wound healing
Key reported benefits — MK-677
- ✓Sustained GH/IGF-1 elevation
- ✓Sleep depth
- ✓Lean mass
- ✓Bone density
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.