GHK-Cu vs Melanotan II
Both GHK-Cu and Melanotan II are used for skin. Here's how their evidence, dosing, and regulatory status actually compare.
GHK-Cu
Evidence B+Copper Peptide GHK-Cu
A naturally occurring copper-binding tripeptide that modulates 4,000+ human genes. The most studied peptide for skin rejuvenation with both preclinical and clinical topical evidence.
View full GHK-Cu profile →Melanotan II
Evidence C+Melanotan II (MT-II)
A non-selective melanocortin agonist (MC1R/MC3R/MC4R) that produces tanning and erection effects. Significant safety concerns including melanoma case reports.
View full Melanotan II profile →Side-by-Side
| Attribute | GHK-Cu | Melanotan II |
|---|---|---|
| Evidence Grade | B+ | C+ |
| FDA Status | Not FDA-approved — available as cosmetic ingredient and research compound | Not FDA-approved — sold illegally as cosmetic; FDA warning letters issued |
| Typical Dose | 1–2 mg daily SC or topical (5 days on / 2 off) | 0.25–1 mg daily during loading, then maintenance (subcutaneous) |
| Clinics Indexed | 145 | 18 |
| Categories | anti-aging, skin, hair | skin, sexual-health |
Key reported benefits — GHK-Cu
- ✓Collagen synthesis
- ✓Wrinkle reduction
- ✓Hair growth
- ✓Wound healing
Key reported benefits — Melanotan II
- ✓UV-independent tanning
- ✓Erectile effect (off-label)
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.