GHK-Cu vs Ipamorelin
Both GHK-Cu and Ipamorelin are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.
GHK-Cu
Evidence B+Copper Peptide GHK-Cu
A naturally occurring copper-binding tripeptide that modulates 4,000+ human genes. The most studied peptide for skin rejuvenation with both preclinical and clinical topical evidence.
View full GHK-Cu profile →Ipamorelin
Evidence BIpamorelin Acetate
A selective growth hormone secretagogue that triggers GH release from the pituitary without significantly raising cortisol or prolactin. The safest GH peptide with the fewest side effects.
View full Ipamorelin profile →Side-by-Side
| Attribute | GHK-Cu | Ipamorelin |
|---|---|---|
| Evidence Grade | B+ | B |
| FDA Status | Not FDA-approved — available as cosmetic ingredient and research compound | Not FDA-approved — Category 1 (compounding allowed) |
| Typical Dose | 1–2 mg daily SC or topical (5 days on / 2 off) | 100–300 mcg before bed (subcutaneous) |
| Clinics Indexed | 145 | 195 |
| Categories | anti-aging, skin, hair | growth-hormone, anti-aging |
Key reported benefits — GHK-Cu
- ✓Collagen synthesis
- ✓Wrinkle reduction
- ✓Hair growth
- ✓Wound healing
Key reported benefits — Ipamorelin
- ✓Clean GH release
- ✓Improved sleep quality
- ✓Fat reduction
- ✓Joint health
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.