GHK-Cu vs Epitalon
Both GHK-Cu and Epitalon are used for anti-aging. Here's how their evidence, dosing, and regulatory status actually compare.
GHK-Cu
Evidence B+Copper Peptide GHK-Cu
A naturally occurring copper-binding tripeptide that modulates 4,000+ human genes. The most studied peptide for skin rejuvenation with both preclinical and clinical topical evidence.
View full GHK-Cu profile →Epitalon
Evidence C+Epitalon (Epithalon, AEDG)
A synthetic tetrapeptide that reportedly upregulates telomerase activity. Russian longevity studies suggest mortality reductions but Western RCTs are absent.
View full Epitalon profile →Side-by-Side
| Attribute | GHK-Cu | Epitalon |
|---|---|---|
| Evidence Grade | B+ | C+ |
| FDA Status | Not FDA-approved — available as cosmetic ingredient and research compound | Not FDA-approved — Russian-origin research peptide |
| Typical Dose | 1–2 mg daily SC or topical (5 days on / 2 off) | 5–10 mg daily for 10–20 days, cycled (subcutaneous) |
| Clinics Indexed | 145 | 47 |
| Categories | anti-aging, skin, hair | anti-aging, longevity |
Key reported benefits — GHK-Cu
- ✓Collagen synthesis
- ✓Wrinkle reduction
- ✓Hair growth
- ✓Wound healing
Key reported benefits — Epitalon
- ✓Telomerase upregulation (preclinical)
- ✓Sleep/circadian normalization
- ✓Anti-aging signals
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.