What is the difference between Epitalon and Humanin?

Epitalon (Epitalon (Epithalon, AEDG)) is graded C+ and is Not FDA-approved — Russian-origin research peptide. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: longevity.

Which has stronger clinical evidence — Epitalon or Humanin?

On our internal evidence scale, Epitalon is C+ and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Epitalon vs Humanin?

Epitalon: 5–10 mg daily for 10–20 days, cycled (subcutaneous). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

Epitalon vs Humanin

Both Epitalon and Humanin are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.

Epitalon

Evidence C+

Epitalon (Epithalon, AEDG)

A synthetic tetrapeptide that reportedly upregulates telomerase activity. Russian longevity studies suggest mortality reductions but Western RCTs are absent.

View full Epitalon profile →

Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	Epitalon	Humanin
Evidence Grade	C+	B
FDA Status	Not FDA-approved — Russian-origin research peptide	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	5–10 mg daily for 10–20 days, cycled (subcutaneous)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	47	5
Categories	anti-aging, longevity	mitochondrial, longevity, neuroprotection

Key reported benefits — Epitalon

✓Telomerase upregulation (preclinical)
✓Sleep/circadian normalization
✓Anti-aging signals

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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