Epitalon vs Glutathione (GSH)
Both Epitalon and Glutathione (GSH) are used for longevity. Here's how their evidence, dosing, and regulatory status actually compare.
Epitalon
Evidence C+Epitalon (Epithalon, AEDG)
A synthetic tetrapeptide that reportedly upregulates telomerase activity. Russian longevity studies suggest mortality reductions but Western RCTs are absent.
View full Epitalon profile →Glutathione (GSH)
Evidence BReduced L-Glutathione
Technically a tripeptide (γ-glutamyl-cysteinyl-glycine) and the body's primary antioxidant. Often grouped with peptide therapy in IV/compounded form for liver support and oxidative stress.
View full Glutathione (GSH) profile →Side-by-Side
| Attribute | Epitalon | Glutathione (GSH) |
|---|---|---|
| Evidence Grade | C+ | B |
| FDA Status | Not FDA-approved — Russian-origin research peptide | Not FDA-approved as therapeutic — sold as supplement; intravenous use compounded |
| Typical Dose | 5–10 mg daily for 10–20 days, cycled (subcutaneous) | 200–600 mg sublingual / 600–2400 mg IV (compounded) |
| Clinics Indexed | 47 | 312 |
| Categories | anti-aging, longevity | antioxidant, longevity |
Key reported benefits — Epitalon
- ✓Telomerase upregulation (preclinical)
- ✓Sleep/circadian normalization
- ✓Anti-aging signals
Key reported benefits — Glutathione (GSH)
- ✓Master antioxidant
- ✓Liver detoxification support
- ✓Oxidative stress reduction
Educational use only
This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.