What is the difference between DSIP and Humanin?

DSIP (Delta Sleep-Inducing Peptide) is graded C and is Not FDA-approved — research compound. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — DSIP or Humanin?

On our internal evidence scale, DSIP is C and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of DSIP vs Humanin?

DSIP: 100–300 mcg before bed (subcutaneous). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

DSIP vs Humanin

Both DSIP and Humanin are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

DSIP

Evidence C

Delta Sleep-Inducing Peptide

A nonapeptide originally isolated from rabbit blood after EEG-defined slow-wave sleep induction. Inconsistent human evidence for sleep but explored for stress and analgesia.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	DSIP	Humanin
Evidence Grade	C	B
FDA Status	Not FDA-approved — research compound	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	100–300 mcg before bed (subcutaneous)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	38	5
Categories	sleep, neuroprotection	mitochondrial, longevity, neuroprotection

Key reported benefits — DSIP

✓Slow-wave-sleep signals (preclinical)
✓Stress/cortisol modulation
✓Possible analgesic effect

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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