What is the difference between Dihexa and Pinealon?

Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). Pinealon (Pinealon (EDR)) is graded C and is Not FDA-approved — Russian-origin research peptide. They are commonly compared because they share the categories: cognitive.

Which has stronger clinical evidence — Dihexa or Pinealon?

On our internal evidence scale, Dihexa is C and Pinealon is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Dihexa vs Pinealon?

Dihexa: 8–45 mg orally daily (research-only). Pinealon: 5–10 mg daily for 10–20 days (subcutaneous, cycled). Always work with a licensed clinician — peptide dosing should be individualized.

Dihexa vs Pinealon

Both Dihexa and Pinealon are used for cognitive. Here's how their evidence, dosing, and regulatory status actually compare.

Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

View full Dihexa profile →

Pinealon

Evidence C

Pinealon (EDR)

A short tripeptide developed in Russia for cognitive aging and oxidative stress. Limited Western clinical evidence.

View full Pinealon profile →

Side-by-Side

Attribute	Dihexa	Pinealon
Evidence Grade	C	C
FDA Status	Not FDA-approved — research compound (HGF/c-Met-mimetic)	Not FDA-approved — Russian-origin research peptide
Typical Dose	8–45 mg orally daily (research-only)	5–10 mg daily for 10–20 days (subcutaneous, cycled)
Clinics Indexed	10	9
Categories	cognitive, neuroprotection	cognitive, longevity

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Key reported benefits — Pinealon

✓Cognitive function (preclinical)
✓Reduced oxidative damage
✓Sleep/circadian effects

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

← Back to all comparisons