What is the difference between Dihexa and Humanin?

Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — Dihexa or Humanin?

On our internal evidence scale, Dihexa is C and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Dihexa vs Humanin?

Dihexa: 8–45 mg orally daily (research-only). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

Dihexa vs Humanin

Both Dihexa and Humanin are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	Dihexa	Humanin
Evidence Grade	C	B
FDA Status	Not FDA-approved — research compound (HGF/c-Met-mimetic)	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	8–45 mg orally daily (research-only)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	10	5
Categories	cognitive, neuroprotection	mitochondrial, longevity, neuroprotection

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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