What is the difference between Dihexa and DSIP?

Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). DSIP (Delta Sleep-Inducing Peptide) is graded C and is Not FDA-approved — research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — Dihexa or DSIP?

On our internal evidence scale, Dihexa is C and DSIP is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Dihexa vs DSIP?

Dihexa: 8–45 mg orally daily (research-only). DSIP: 100–300 mcg before bed (subcutaneous). Always work with a licensed clinician — peptide dosing should be individualized.

Dihexa vs DSIP

Both Dihexa and DSIP are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

View full Dihexa profile →

DSIP

Evidence C

Delta Sleep-Inducing Peptide

A nonapeptide originally isolated from rabbit blood after EEG-defined slow-wave sleep induction. Inconsistent human evidence for sleep but explored for stress and analgesia.

View full DSIP profile →

Side-by-Side

Attribute	Dihexa	DSIP
Evidence Grade	C	C
FDA Status	Not FDA-approved — research compound (HGF/c-Met-mimetic)	Not FDA-approved — research compound
Typical Dose	8–45 mg orally daily (research-only)	100–300 mcg before bed (subcutaneous)
Clinics Indexed	10	38
Categories	cognitive, neuroprotection	sleep, neuroprotection

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Key reported benefits — DSIP

✓Slow-wave-sleep signals (preclinical)
✓Stress/cortisol modulation
✓Possible analgesic effect

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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