What is the difference between Cerebrolysin and Humanin?

Cerebrolysin (Cerebrolysin (porcine brain peptide complex)) is graded B and is Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — Cerebrolysin or Humanin?

On our internal evidence scale, Cerebrolysin is B and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Cerebrolysin vs Humanin?

Cerebrolysin: Trial range: 5–30 mL daily (intravenous infusion). Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

Cerebrolysin vs Humanin

Both Cerebrolysin and Humanin are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Cerebrolysin

Evidence B

Cerebrolysin (porcine brain peptide complex)

A standardized mixture of low-molecular-weight peptides from porcine brain. Decades of stroke, dementia, and TBI trial data — modest but consistent cognitive recovery effects.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	Cerebrolysin	Humanin
Evidence Grade	B	B
FDA Status	Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	Trial range: 5–30 mL daily (intravenous infusion)	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	41	5
Categories	cognitive, neuroprotection	mitochondrial, longevity, neuroprotection

Key reported benefits — Cerebrolysin

✓Stroke recovery support
✓TBI rehabilitation
✓Cognitive function in dementia

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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