What is the difference between Cerebrolysin and Dihexa?

Cerebrolysin (Cerebrolysin (porcine brain peptide complex)) is graded B and is Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia. Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). They are commonly compared because they share the categories: cognitive, neuroprotection.

Which has stronger clinical evidence — Cerebrolysin or Dihexa?

On our internal evidence scale, Cerebrolysin is B and Dihexa is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of Cerebrolysin vs Dihexa?

Cerebrolysin: Trial range: 5–30 mL daily (intravenous infusion). Dihexa: 8–45 mg orally daily (research-only). Always work with a licensed clinician — peptide dosing should be individualized.

Cerebrolysin vs Dihexa

Both Cerebrolysin and Dihexa are used for cognitive and neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

Cerebrolysin

Evidence B

Cerebrolysin (porcine brain peptide complex)

A standardized mixture of low-molecular-weight peptides from porcine brain. Decades of stroke, dementia, and TBI trial data — modest but consistent cognitive recovery effects.

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Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

View full Dihexa profile →

Side-by-Side

Attribute	Cerebrolysin	Dihexa
Evidence Grade	B	C
FDA Status	Not FDA-approved in US — approved in 50+ countries for stroke, traumatic brain injury, and dementia	Not FDA-approved — research compound (HGF/c-Met-mimetic)
Typical Dose	Trial range: 5–30 mL daily (intravenous infusion)	8–45 mg orally daily (research-only)
Clinics Indexed	41	10
Categories	cognitive, neuroprotection	cognitive, neuroprotection

Key reported benefits — Cerebrolysin

✓Stroke recovery support
✓TBI rehabilitation
✓Cognitive function in dementia

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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