What is the difference between ARA-290 and Humanin?

ARA-290 (ARA-290 (Cibinetide)) is graded B and is Not FDA-approved — Phase 2/3 trials for sarcoidosis-associated small fiber neuropathy. Humanin (Humanin (HN)) is graded B and is Not FDA-approved — mitochondrial-derived peptide research compound. They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — ARA-290 or Humanin?

On our internal evidence scale, ARA-290 is B and Humanin is B. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of ARA-290 vs Humanin?

ARA-290: Trial range: 1–4 mg subcutaneous daily. Humanin: Research range: 0.5–1 mg subcutaneous (rare clinical use). Always work with a licensed clinician — peptide dosing should be individualized.

ARA-290 vs Humanin

Both ARA-290 and Humanin are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

ARA-290

Evidence B

ARA-290 (Cibinetide)

An 11-amino-acid peptide derived from the helix-B region of erythropoietin. Activates the tissue-protective receptor without erythropoietic side effects. Investigated for neuropathy and inflammation.

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Humanin

Evidence B

Humanin (HN)

A 24-amino-acid mitochondrial-derived peptide with cytoprotective effects across Alzheimer's, diabetes, and atherosclerosis preclinical models. Endogenous levels decline sharply with age.

View full Humanin profile →

Side-by-Side

Attribute	ARA-290	Humanin
Evidence Grade	B	B
FDA Status	Not FDA-approved — Phase 2/3 trials for sarcoidosis-associated small fiber neuropathy	Not FDA-approved — mitochondrial-derived peptide research compound
Typical Dose	Trial range: 1–4 mg subcutaneous daily	Research range: 0.5–1 mg subcutaneous (rare clinical use)
Clinics Indexed	9	5
Categories	anti-inflammatory, neuroprotection	mitochondrial, longevity, neuroprotection

Key reported benefits — ARA-290

✓Small-fiber neuropathy improvement
✓Anti-inflammatory
✓No erythrocytosis

Key reported benefits — Humanin

✓Cytoprotection
✓Anti-amyloid effects
✓Insulin sensitization

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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