What is the difference between ARA-290 and Dihexa?

ARA-290 (ARA-290 (Cibinetide)) is graded B and is Not FDA-approved — Phase 2/3 trials for sarcoidosis-associated small fiber neuropathy. Dihexa (Dihexa (PNB-0408)) is graded C and is Not FDA-approved — research compound (HGF/c-Met-mimetic). They are commonly compared because they share the categories: neuroprotection.

Which has stronger clinical evidence — ARA-290 or Dihexa?

On our internal evidence scale, ARA-290 is B and Dihexa is C. A+ indicates large RCTs plus FDA approval; C indicates primarily preclinical or anecdotal evidence.

What is the typical dose of ARA-290 vs Dihexa?

ARA-290: Trial range: 1–4 mg subcutaneous daily. Dihexa: 8–45 mg orally daily (research-only). Always work with a licensed clinician — peptide dosing should be individualized.

ARA-290 vs Dihexa

Both ARA-290 and Dihexa are used for neuroprotection. Here's how their evidence, dosing, and regulatory status actually compare.

ARA-290

Evidence B

ARA-290 (Cibinetide)

An 11-amino-acid peptide derived from the helix-B region of erythropoietin. Activates the tissue-protective receptor without erythropoietic side effects. Investigated for neuropathy and inflammation.

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Dihexa

Evidence C

Dihexa (PNB-0408)

An angiotensin IV-derived hexapeptide that mimics hepatocyte growth factor (HGF)/c-Met signaling and produced rapid synaptogenesis in animal models. No human trials.

View full Dihexa profile →

Side-by-Side

Attribute	ARA-290	Dihexa
Evidence Grade	B	C
FDA Status	Not FDA-approved — Phase 2/3 trials for sarcoidosis-associated small fiber neuropathy	Not FDA-approved — research compound (HGF/c-Met-mimetic)
Typical Dose	Trial range: 1–4 mg subcutaneous daily	8–45 mg orally daily (research-only)
Clinics Indexed	9	10
Categories	anti-inflammatory, neuroprotection	cognitive, neuroprotection

Key reported benefits — ARA-290

✓Small-fiber neuropathy improvement
✓Anti-inflammatory
✓No erythrocytosis

Key reported benefits — Dihexa

✓Synaptogenesis (preclinical)
✓Memory improvement (animal)
✓Possible Alzheimer's relevance

Educational use only

This comparison is for educational purposes and not medical advice. Peptide selection should be made with a licensed medical professional based on your individual goals, health history, and current evidence quality.

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